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For ONT sequencing, most improvement efforts have been focused on base-callers. These tools were originally based on Hidden Markov Models88 (HMMs), but gradually they have been shifting over to neural network based deep learning methods53,74,89,90 with faster inference times and better performance.
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"I don't know how I feel about the government getting involved in allowing and dictating who is ready to go into the mountains and who's not," says Rebekah. "Part of the beauty of the mountains is that you can push yourself at your own pace, at your own limits."