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The Clean Architecture was an attempt to unify Hex, Onion and other application architectures.
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In its early days, sequencing was a laborious (and literally radioactive) biochemical process. Today, sequencing machines are ubiquitous, safe, and much less labor-intensive. This evolution was enabled not just by advances in biochemistry but insights from biophysics and materials science, as well as manufacturing ingenuity that turned lab sequencing setups into machines ready for shipping to customers.